Beilstein J. Org. Chem.2018,14, 2035–2064, doi:10.3762/bjoc.14.179
immediately obvious application of this bioconjugation to biochemistry and molecular biology as a tool for proteinlabelling, it could also be used as a convenient tool for peptide chemists in medicinal chemistry programs for modification of peptides.
2.2 C(sp2)–C(sp2) bond formation
Suzuki–Miyaura and
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Graphical Abstract
Figure 1:
Depiction of the energy levels of a typical organic molecule and the photophysical processes it can...
Beilstein J. Org. Chem.2016,12, 2784–2792, doi:10.3762/bjoc.12.277
for the development of customized PqsD inhibitors as well as a chemical toolbox to investigate the activity and active site specificity of the enzyme.
Keywords: activity-based probes; PqsD; proteinlabelling; Pseudomonas aeruginosa; quinolones; Introduction
The emergence of multi-drug resistant
potential inactivation of the probe by the compound scaffold during proteinlabelling could be ruled out (Supporting Information File 1, Figures S4 and S5).
Our 4S-PQS analogues thus represent a promising novel scaffold that inhibits the labelling of PqsD by an active-site-directed probe in the lower
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Graphical Abstract
Figure 1:
Quinolone signals of Pseudomonas aeruginosa. A) Structures of HHQ and PQS. B) Proposed mechanism fo...